Until around June 2009, Moby co-owned a small restaurant and tea shop called TeaNY, where he occasionally waited tables. He also organized the Little Idiot Collective, a group of artists. Moby lives a vegan lifestyle and supports animal rights.
In an interview with Psychology Today, Moby stated that when he was 19, he tried LSD and began suffering from panic attacks. He claims that he no longer experiences them as frequently as he used to, but occasionally he will "have too much caffeine, be stressed out about work and be in a relationship that's not going well, and it will happen again." He is very open about this in an attempt to help fans who suffer from similar panic disorders.
When asked about drugs, he responded: "I'm sort of a libertarian. People should be able to do what they want. I ultimately defer the wisdom to an adult to make their own choices. If someone wants to do drugs, I think it's their own business and not the business of the state."
In a 2003 BBC interview, Moby spoke about his encounter with the Gospels, "In about 1985 I read the teachings of Christ and was instantly struck by the idea that Christ was somehow divine. When I say I love Christ and love the teachings of Christ I mean that in the most simple and naïve and subjective way. I'm not saying I'm right, and I certainly wouldn't criticize anyone else's beliefs." In an interview with amazon.com, Moby said, "I can't really know anything. Having said that, though, on a very subjective level I love Christ. I perceive Christ to be God, but I predicate that with the knowledge that I'm small and not nearly as old as the universe that I live in. I take my beliefs seriously for myself, but I would be very uncomfortable trying to tell anyone that I was right."
In a September 20, 2006 audio interview with Sojourners magazine, he says, "I read the New Testament, specifically the gospels and I was struck at their divinity, feeling that humans could not have figured this out on their own. We're just not bright enough." He also discusses his faith on his own weblog. On January 19, 2007, in his reaction to seeing Alexandra Pelosi's Friends of God, a film about evangelism in the United States, Moby writes, "The movie reminded me just how utterly disconnected the agenda of the evangelical Christian right is from the teachings of Christ."
In March 2008, after Gary Gygax's death, Moby was one of several celebrities stating they had been Dungeons & Dragons players.
In March 2010, Moby made his debut as an author when Gristle: From Factory Farms to Food Safety (Thinking Twice About the Meat We Eat), a collection of essays from people in the food industry, was published.
Moby is an advocate for a variety of causes, working with MoveOn and The Humane Society, among others. His MobyGratis.com website, which licenses film music for free for non-profit and independent films, funnels proceeds from films which do go on to produce revenue to The Humane Society. He created MoveOn Voter Fund's Bush in 30 Seconds contest along with singer/ MoveOn Cultural Director Laura Dawn and MoveOn Executive Director Eli Pariser. The music video for the song "Disco Lies" from Last Night has heavy anti-meat industrial themes.
He also actively engages in nonpartisan activism, and serves on the Board of Directors of Amend.org, a nonprofit that implements injury prevention programs in Africa.
Moby is a member of the Board of Directors of the Institute for Music and Neurologic Function (IMNF), a not-for-profit organization dedicated to advancing scientific inquiry on music and the brain and to developing clinical treatments to benefit people of all ages. He has also performed on various benefit concerts to help increase awareness for music therapy and raise funds for the Institute. In 2004, he was honored with the IMNF’s 'Music Has Power Award' for his advocacy of music therapy and for his dedication and support to its recording studio program.
He is an advocate of network neutrality and he testified before United States House of Representatives committee debating the issue in 2006.
In 2008 he participated in a music album called Songs for Tibet, to support Tibet and the current Dalai Lama Tenzin Gyatso.
In 2009 after hearing about California cutting its funding to domestic violence programs, Moby decided to donate the fees from his tour shows in L.A. and San Francisco to the California Partnership to End Domestic Violence.
Many Moby albums include essays that he has written himself in the inlay card. Everything Is Wrong had essays on over-consumption ("We use toxic chlorine bleach to keep our underpants white") and U.S. religious leaders ("Why doesn't the Christian right go out and spread mercy, compassion and selflessness?"), and The End of Everything discussed being a vegan ("Could you look an animal in the eyes and say to it, 'My appetite is more important than your suffering'?").
He was interviewed by Lucy Walker for a chapter in Sound Unbound: Sampling Digital Music and Culture (The MIT Press, 2008) edited by Paul D. Miller a.k.a. DJ Spooky.